Dimethylformamide → 2-(3-Amino-4-bromo-5-phenyl-pyrazol-1-yl)-1-[4-(4-bromo-3-methoxyphenyl)-piperazin-1-yl]-ethanone

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Bromo-3-phenyl-1H-pyrazol-5-amine	HCID 594319	—
반응물	2-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone	HCID 21071125	—
용매	Ethyl acetate hexane	HCID 21226206	—
생성물	2-(3-Amino-4-bromo-5-phenyl-pyrazol-1-yl)-1-[4-(4-bromo-3-methoxyphenyl)-piperazin-1-yl]-ethanone	HCID 21071042	—

반응 단계

Protocol T was followed using 4-Bromo-5-phenyl-1H-pyrazol-3-ylamine, K2CO3, 2-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1.5) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 7.78-7.84 (d, 2H), 7.32-7.42 (m, 3H), 7.18-7.22 (d, 1H), 6.44-6.52 (d, 1H), 6.36-6.42 (dd, 1H), 4.94 (s, 2H), 4.28 (s, 2H), 3.84 (s, 3H), 3.76-3.82 (m, 4H), 3.12-3.18 (m, 4H). 13C NMR (400 MHz, CDCl3): 164.6, 154.8, 150.2, 144.6, 130, 128.8, 128.6, 126.4, 109.2, 102, 56, 51, 50, 49.6, 45.6, 42.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07449576B1
출처 데이터셋	uspto-grants-2008_11
ORD ID	ord-575051d6dbd845a4b2350592fd68712e
출처 메모	uspto-grants-2008_11