Methanol → Methyl 4-Iodophenylacetate

HRID 270934

반응식

HRID 270934 반응식
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.S(Cl)(Cl)=O.[CH3:16]O>>[CH3:16][O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([I:1])=[CH:7][CH:6]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 1372144-Iodophenylacetic acid

생성물 1

HCID 10378700Methyl 4-Iodophenylacetate수율 86%

실험 절차

A solution of 5 g (19 mmol) of (4-iodo-phenyl)-acetic acid in 50 mL of methanol (MeOH) was added dropwise 3.5 mL (48 mmol) of thionyl chloride (SOCl2), and the resulting mixture was stirred at rt for 36 h, after which time analysis by thin layer chromatography (TLC) indicated product formation. The mixture was concentrated to give 4.5 g (86% yield) of (4-iodo-phenyl)-acetic acid methyl ester as a pale beige oil as indicated by 1H NMR.

후처리

  1. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-f7d5cee144ee476c8bae7139ebf4f257
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449488B2

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