Cyclohexyl methyl ketone → 1-Cyclohexyl-3-dimethylamino-propenone

HRID 270947

반응식

HRID 270947 반응식
[CH3:1][C:2]([CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=O.C([O:14][CH:15](N(C)C)[N:16]([CH3:18])[CH3:17])(C)(C)C>>[CH3:17][N:16]([C:15](/[CH:1]=[CH:2]/[CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:14])[CH3:18]

참가 물질

3

반응물 2

HCID 13207Cyclohexyl methyl ketoneHCID 79885tert-Butoxy bis(dimethylamino)methane

생성물 1

HCID 110952411-Cyclohexyl-3-dimethylamino-propenone수율 93%

실험 절차

A mixture of 3.0 g (23.8 mmol) of cyclohexyl methyl ketone and 4.56 g (26.2 mmol) of t-butoxybis(dimethylamino)methane (Bredereck's reagent) was stirred at 60□C overnight. The reaction mixture was then concentrated to give 4.0 g (93% yield) of 1-cyclohexyl-3-dimethylamino-propenone as an orange oil as indicated by 1H NMR. This product was used in the next reaction without any further purification.

후처리

  1. concentrationThe reaction mixture was then concentrated

출처 및 근거

ORD 기록
ord-3a3f23ec32f84465a1fab219ed0a5fba
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449488B2

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