2-(3-Phthalimidopropylthio)oxazole → 2-(3-Aminopropyl)thiooxazole
반응식
[H-].NN.C1(=O)[N:8]([CH2:9][CH2:10][CH2:11][S:12][C:13]2[O:14][CH:15]=[CH:16][N:17]=2)C(=O)C2=CC=CC=C12>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][S:12][C:13]1[O:14][CH:15]=[CH:16][N:17]=1참가 물질
4
실험 절차
Hydrazine hydride (5.3 g) was added carefully to a solution of 2-(3-phthalimidopropylthio)oxazole (10 g) in ethanol (173 ml) with stirring. The solution was then heated under reflux for 25 minutes. After cooling, and filtration from phthalhydrazide, the filtrate was concentrated under reduced pressure and the residue was re-evaporated with ethanol to yield crude 2(3-aminopropylthio)oxazole.
후처리
- temperatureThe solution was then heated
- temperatureunder reflux for 25 minutes
- temperatureAfter cooling
- filtrationfiltration from phthalhydrazide
- concentrationthe filtrate was concentrated under reduced pressure
- customthe residue was re-evaporated with ethanol
출처 및 근거
- ORD 기록
- ord-2a2d45b33fe34b379325f1a20a9987c9
- 출처 데이터셋
- uspto-grants-1980_09
- 특허 번호
- US04220652
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