참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 8-Iodo-3-(phenylsulfonyl)quinoline | HCID 11406774 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | Bis(cyclopenta-2,4-dien-1-yl(phenyl)phosphane);iron(2+) | HCID 133083342 | — |
| 생성물 | 8-(4-Methyl-piperazin-1-yl)-3phenylsulfonylquinoline | HCID 9929162 | — |
반응 단계
8-Iodo-3-phenylsulfonyl-quinoline (D6) (190 mg, 0.48 mmol), N-methyl-piperazine (48 mg, 0.48 mmol), sodium tertbutoxide (65 mg, 0.68 mmol), di-palladium tetrakis-(dibenzylidine acetone) [Pd2(dba)3] (88 mg, 0.1 mmol) and 1,1′-diphenylphosphino ferrocene (161 mg, 0.3 mmol) were suspended in degassed dry dioxan (2 ml). The mixture was stirred under argon at 40° C. for 16 hours. The solvent was removed and the residue subjected to flash chromatography on silica gel (eluting with dichloromethane—methanol aq. ammonia) to give the title compound (E1), identical spectroscopically to that prepared by the earlier methods.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07452888B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_11 |
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| ORD ID | ord-c336f4147dc6407d896f11bf4a407ad4 |
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| 출처 메모 | uspto-grants-2008_11 |
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