n-[(3r)-1-(4-Chlorophenyl)-2-oxopyrrolidin-3-yl](phenylmethoxy)carboxamide → (3R)-3-amino-1-(4-chlorophenyl)pyrrolidin-2-one
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@@H:10]([NH:13]C(OCC3C=CC=CC=3)=O)[C:9]2=[O:24])=[CH:4][CH:3]=1>C(O)C.C1CCCCC=1.[OH-].[Pd+2].[OH-]>[NH2:13][C@@H:10]1[CH2:11][CH2:12][N:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:9]1=[O:24]참가 물질
5
실험 절차
To a solution of N-[(3R)-1-(4-chlorophenyl)-2-oxopyrrolidin-3-yl](phenylmethoxy)carboxamide (0.2 g, 0.58 mmol) in ethanol (10 ml) and cyclohexene (4 ml) was added palladium hydroxide (40 mg). The reaction was refluxed vigorously overnight. Palladium was removed by filtration and the filtrate was concentrated to yield (3R)-3-amino-1-(4-chlorophenyl)pyrrolidin-2-one.
후처리
- temperatureThe reaction was refluxed vigorously overnight
- customPalladium was removed by filtration
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-9704df48e6c64055b65f54956a2424ab
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07452889B2
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