Triethylamine → 9-(4-tert-Butylphenylsulphonyl)-6-(2-furyl)-9H-purine-2-amine

HRID 271258

반응식

HRID 271258 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[NH:14][C:13]([NH2:15])=[N:12][C:11]2[C:7]=1[N:8]=[CH:9][N:10]=2.[C:16]([C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1)([CH3:19])([CH3:18])[CH3:17].CCN(CC)CC>C1COCC1.CN(C=O)C.O>[C:16]([C:20]1[CH:25]=[CH:24][C:23]([S:26]([N:10]2[CH:9]=[N:8][C:7]3[C:11]2=[N:12][C:13]([NH2:15])=[N:14][C:6]=3[C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)(=[O:28])=[O:27])=[CH:22][CH:21]=1)([CH3:19])([CH3:17])[CH3:18]

참가 물질

7

반응물 3

HCID 8471TriethylamineHCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 1785082476-(furan-2-yl)-9H-purin-2-amine

생성물 1

HCID 598350419-(4-tert-Butylphenylsulphonyl)-6-(2-furyl)-9H-purine-2-amine수율 53.3%

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

A solution of 6-(2-furyl)-1H-purine-2-amine (100 mg, 0.5 mmol) in THF (2 mL) and DMF (0.5 mL) was treated with 4-tert-butylbenzenesulphonyl chloride (116 mg, 0.5 mmol) and Et3N (69 μL, 0.6 mmol), heated at 60° C. for 2 h, cooled, diluted with water and the resulting solid filtered and washed with EtOAc to give the title compound (106 mg, 53%) as a cream solid.

후처리

  1. temperaturecooled
  2. filtrationthe resulting solid filtered
  3. washwashed with EtOAc

출처 및 근거

ORD 기록
ord-9f7350dd144c4e8ab165d5d6335c9ddb
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452894B2

연결된 노트

불러오는 중…