Methanol → Dimethyl 2,6-dichloroterephthalate

HRID 271321

반응식

[CH3:1]CCCCC.C[Si](C=[N+]=[N-])(C)C.[Cl:14][C:15]1[CH:23]=[C:22]([C:24]([OH:26])=[O:25])[CH:21]=[C:20]([Cl:27])[C:16]=1[C:17](O)=[O:18].[CH3:28][OH:29]>>[CH3:28][O:29][C:17](=[O:18])[C:16]1[C:15]([Cl:14])=[CH:23][C:22]([C:24]([O:26][CH3:1])=[O:25])=[CH:21][C:20]=1[Cl:27]

참가 물질

반응물 4

HCID 887Methanol

HCID 8058Hexane

HCID 39047Benzenedicarboxylic acid, dichloro-

HCID 167693Trimethylsilyldiazomethane

생성물 1

HCID 7730227Dimethyl 2,6-dichloroterephthalate

실험 절차

A hexane solution containing 2M trimethylsilyldiazomethane was added to the mixture of 500 mg of 2,6-dichloro-4-carboxybenzoic acid (Maybridge) and 15 ml of methanol until the end point of the reaction. The reaction mixture was concentrated and purified by silica gel chromatography (ethyl acetate/hexane) to obtain the title compound.

후처리

concentrationThe reaction mixture was concentrated
custompurified by silica gel chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록: ord-fc1d77526f5a496197f73c5430a878e3
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07452905B2

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