Tributyltin azide → HCID 178498353, 화합물
반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1[C:9]([Cl:10])=[CH:8][C:7]([C:11]#[N:12])=[CH:6][C:5]=1[Cl:13].[N:15]([Sn](CCCC)(CCCC)CCCC)=[N+:16]=[N-:17]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3](=[O:14])[C:4]1[C:5]([Cl:13])=[CH:6][C:7]([C:11]2[NH:17][N:16]=[N:15][N:12]=2)=[CH:8][C:9]=1[Cl:10]참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
The mixture of 185 mg of 2,6-dichloro-4-cyanobenzoic acid methylester, 266 mg of azidotributyltin and 5 ml of toluene was stirred at 100° C. for 3 days. The reaction mixture was concentrated and diluted with ethyl acetate. After Celite filtration, the filtrate was concentrated and the residue was purified by reverse phase HPLC to obtain the title compound.
후처리
- concentrationThe reaction mixture was concentrated
- additiondiluted with ethyl acetate
- filtrationAfter Celite filtration
- concentrationthe filtrate was concentrated
- customthe residue was purified by reverse phase HPLC
출처 및 근거
- ORD 기록
- ord-2fdbb417753a459193cf47bd0c0624b8
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07452905B2
반응 노트
불러오는 중…