Bromine → 5-Bromo-6-chloropyrimidine-2,4-diol

HRID 271422

반응식

HRID 271422 반응식
[Cl:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.[Br:10]Br>O>[Br:10][C:3]1[C:4](=[O:9])[NH:5][C:6](=[O:8])[NH:7][C:2]=1[Cl:1]

참가 물질

4

반응물 2

HCID 24408BromineHCID 732726-Chlorouracil

생성물 1

HCID 5898345-Bromo-6-chloropyrimidine-2,4-diol수율 61.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirring and refluxing solution of 6-chloropyrimidine-2,4(1H,3H)-dione (10.0 g, 68.25 mmol) in water (100 mL) was added bromine (4 mL, 79.84 mmol)) over 10 min. The colorless precipitate that formed was collected by filtration, washed with water (50 mL×2), and dried in a vacuum oven at 50° C. overnight, to obtain 9.4 g of the title compound as a white solid. HPLC/MS: retention time=1.05 min, [M+H]30 =225.

후처리

  1. customThe colorless precipitate that formed
  2. filtrationwas collected by filtration
  3. washwashed with water (50 mL×2)
  4. customdried in a vacuum oven at 50° C. overnight

출처 및 근거

ORD 기록
ord-36f4b4f8f9444ba68960dafb5f4540de
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452892B2

연결된 노트

불러오는 중…