Water → 4-Ethylsulfonylbenzoic acid

HRID 271473

반응식

HRID 271473 반응식
[CH2:1]([S:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)[CH3:2].S([O-])(O[O-])(=O)=[O:14].[K+].[K+].[OH2:21]>CO>[CH2:1]([S:3]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)(=[O:14])=[O:21])[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 832314-(Ethylthio)benzoic acidHCID 10313463Potassium peroxymonosulphate

생성물 1

HCID 1793674-Ethylsulfonylbenzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirring solution of 4-(ethylthio)benzoic acid (1 g, 5.5 mmol) in methanol (30 mL) at 0° C. under argon was added a solution of potassium peroxymonosulfate (6.8 g, 11 mmol) in water (30 mL). The resulted suspension was stirred at room temperature for 15 h. Methanol was evaporated under vacuum, the reaction mixture was diluted with water (30 mL), and the product was extracted with EtOAc (2×30 mL). The combined organic phase was washed with saturated aqueous NaCl, dried (MgSO4), filtered and concentrated under reduced pressure to obtain 910 mg of title compound as a white solid. HPLC/MS: retention time=1.695 min, [M+H]+=215.

후처리

  1. customMethanol was evaporated under vacuum
  2. additionthe reaction mixture was diluted with water (30 mL)
  3. extractionthe product was extracted with EtOAc (2×30 mL)
  4. washThe combined organic phase was washed with saturated aqueous NaCl
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b72705c2182d4eceafbc4e79c2daa821
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452892B2

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