Thionyl Chloride → 1-(Chloromethyl)-4-(ethylsulfonyl)benzene

HRID 271475

반응식

HRID 271475 반응식
[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12]O)=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2].S(Cl)([Cl:16])=O>ClCCl>[Cl:16][CH2:12][C:9]1[CH:10]=[CH:11][C:6]([S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 572424(4-(Ethylsulfonyl)phenyl)methanol

생성물 1

HCID 598347911-(Chloromethyl)-4-(ethylsulfonyl)benzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of (4-(ethylsulfonyl)phenyl)methanol (200 mg, 1 mmol) and thionyl chloride (3 mL) was stirred at reflux for 4 h. The solvent was removed under reduced pressure to obtain a gum. Dichloromethane (10 mL) was added, and the mixture was stirred for 5 min and then concentrated under vacuum. This process was repeated two more times to ensure complete removal of thionyl chloride. After residual solvent removal under vacuum, 205 mg of the title compound was obtained as a white solid. HPLC/MS: retention time=2.308 min, [M+H]+=219.

후처리

  1. temperatureat reflux for 4 h
  2. customThe solvent was removed under reduced pressure
  3. customto obtain a gum
  4. stirringthe mixture was stirred for 5 min
  5. concentrationconcentrated under vacuum
  6. customremoval of thionyl chloride
  7. customAfter residual solvent removal under vacuum

출처 및 근거

ORD 기록
ord-da6685ace886414ead9b8f1d80fdfa93
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452892B2

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