6-Chloromethyl-2-methylpyridinium chloride → 3-[2-Methyl-1-(6-methyl-pyridin-2-ylmethyl)-1H-imidazol-4-ylethynyl]-benzonitrile

반응식

[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1.Cl.Cl[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[N:21]=1>>[CH3:1][C:2]1[N:3]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[N:21]=2)[CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1

참가 물질

반응물 2

HCID 765456-Chloromethyl-2-methylpyridinium chloride

HCID 178432699HCID 178432699, 화합물

생성물 1

HCID 672480443-[2-Methyl-1-(6-methyl-pyridin-2-ylmethyl)-1H-imidazol-4-ylethynyl]-benzonitrile

실험 절차

The title compound, MS: m/e=313.2 (M+H30), was prepared in accordance with the general method of example 1 from 3-(2-methyl-1H-imidazol-4-ylethynyl)-benzonitrile and 2-chloromethyl-6-methyl-pyridine hydrochloride.

출처 및 근거

ORD 기록: ord-89dd756eb32a486fa3345ca74b4d75d9
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07452909B2

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