Methanol → Tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate

HRID 271583노트

반응식

HRID 271583 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15](=[O:18])([O-])[O-].[NH4+:19].[NH4+:20].[C-]#N.[Na+].[CH3:24][OH:25]>O>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2([NH:20][C:24](=[O:25])[NH:19][C:15]2=[O:18])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 887MethanolHCID 8929Sodium CyanideHCID 517111Ammonium CarbonateHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

생성물 1

HCID 3629994Tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (30.0 g, 151 mmol) in MeOH (100 ml), H2O (40 ml), ammonium carbonate (331 mmol) and sodium cyanide (226 mmol) in H2O (60 ml) are added successively at ambient temperature. The reaction mixture is stirred at ambient temperature for 18 h to give precipitates, which are filtered off and washed with H2O and ether on the filter.

후처리

  1. customto give
  2. customprecipitates
  3. filtrationwhich are filtered off
  4. washwashed with H2O and ether on the filter

출처 및 근거

ORD 기록
ord-1ca84f2ff9f141c9b27bb55cbb4e946b
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452886B2

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