Tetrabutylammonium Fluoride → 3-(4-Chloro-phenyl)-6-ethynyl-pyridazine

HRID 271704노트

반응식

HRID 271704 반응식
CCCC[N+](CCCC)(CCCC)CCCC.[F-].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:27]=[N:28][C:29]([C:32]#[C:33][Si](C)(C)C)=[CH:30][CH:31]=2)=[CH:22][CH:21]=1>C(Cl)Cl>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[N:27]=[N:28][C:29]([C:32]#[CH:33])=[CH:30][CH:31]=2)=[CH:24][CH:25]=1

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 673622923-(4-Chloro-phenyl)-6-trimethylsilanylethynyl-pyridazine

생성물 1

HCID 859696873-(4-Chloro-phenyl)-6-ethynyl-pyridazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.10 g (3.49 mmol) TBAF are added at 0° C. to a solution of 1.00 g (3.49 mmol) 3-(4-chloro-phenyl)-6-trimethylsilanylethynyl-pyridazine in 10 mL DCM. The ice bath is removed and the reaction solution is stirred for 30 min. Water is added and the aqueous phase is extracted with EtOAc. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac. The product is reacted without any further purification.

후처리

  1. customThe ice bath is removed
  2. additionWater is added
  3. extractionthe aqueous phase is extracted with EtOAc
  4. dry with materialThe organic phase is dried over MgSO4
  5. customThe product is reacted without any further purification

출처 및 근거

ORD 기록
ord-d6e5ce41cbd94d4b817f088f7df52584
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452911B2

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