m-Chloroperbenzoic acid → HCID 178452066, 화합물

HRID 271869

반응식

HRID 271869 반응식
[O:1]=[C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]1[CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1.ClC1C=C(C=CC=1)C(OO)=[O:29]>ClCCCl>[O-:29][N+:6]1[CH:7]=[CH:8][CH:9]=[C:4]2[N:3]([CH:11]3[CH2:12][CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15][CH2:16]3)[C:2](=[O:1])[NH:10][C:5]=12

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 22293220tert-butyl 4-{2-oxo-1H,2H,3H-imidazo[4,5-b]pyridin-1-yl}piperidine-1-carboxylate

생성물 1

HCID 178452066HCID 178452066, 화합물수율 68%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

2-Oxo-1-(1-t-butoxycarbonylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine (63 mg, 0.198 mmol) was dissolved in 1,2-dichloroethane (10 mL) and 3-chloroperoxybenzoic acid (137 mg, 0.792 mmol) was added at 0° C. The reaction was warmed to room temperature and stirred for 4 h. The reaction was quenched with saturated aqueous sodium bicarbonate and sodium thiosulfate, extracted with methylene chloride (3×), dried over sodium sulfate, filtered and evaporated to give the title compound (45 mg). MS 335.1 (M+1).

후처리

  1. customThe reaction was quenched with saturated aqueous sodium bicarbonate and sodium thiosulfate
  2. extractionextracted with methylene chloride (3×)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-45f7672083b245a3912dc1a8f9daa5ea
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07452903B2

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