Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-(3-Methoxyphenyl)-2-oxopropanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Acetylglycine | HCID 10972 | — |
| 반응물 | 3-Methoxybenzaldehyde | HCID 11569 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetic Anhydride | HCID 7918 | — |
| 생성물 | 3-(3-Methoxyphenyl)-2-oxopropanoic acid | HCID 290091 | 34.1% |
반응 단계
m-Anisaldehyde (25.9 g), N-acetylglycine (15.2 g) and sodium acetate (7.8 g) were heated together under reflux in acetic anhydride (50 ml) for 3/4 hour. The mixture was allowed to cool, water (150 ml) was added and the mixture was filtered to give the crude azlactone (27.7 g) m.p. 145°-150°. Hydrolysis with boiling 1 N hydrochloric acid (450 ml) followed by cooling and ether extraction afforded 3-methoxyphenylpyruvic acid as a pale yellow oily solid (6.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04220767 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-0d710401d4e548719286207680e38f38 |
| 출처 메모 | uspto-grants-1980_09 |