HCID 45263090, 화합물 → 8-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 27247노트

반응식

HRID 27247 반응식
[ClH:1].C([N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:13]=[CH:14][CH:15]=2)[CH2:10]1)C1C=CC=CC=1>[Pd].C(O)C>[ClH:1].[C:19]1([C:12]2[CH:13]=[CH:14][CH:15]=[C:16]3[C:11]=2[CH2:10][NH:9][CH2:18][CH2:17]3)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

4

반응물 1

HCID 45263090HCID 45263090, 화합물

생성물 1

HCID 452657048-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 6.20 parts of 2-benzyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride and 0.62 parts of 5% palladium-on-carbon catalyst in 100 parts by volume of ethanol is hydrogenated at 2 psi and ambient temperature for about 6 hours. The filtered reaction solution is concentrated to 75 parts by volume and after the addition of ether crystalline solid is formed. This solid is recrystallized from ethanol to yield 8-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride, as white crystals melting at about 268°-270° C. This compound has the following formula ##STR17##

후처리

  1. customThe filtered reaction solution
  2. concentrationis concentrated to 75 parts by volume
  3. additionafter the addition of ether crystalline solid
  4. customis formed
  5. customThis solid is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-63e525c625584e91b3679d9e3bb16686
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220778

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