Acetyl chloride → 2-Acetyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline

HRID 27248노트

반응식

HRID 27248 반응식
[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:16]=2[CH2:15][NH:14][CH2:13][CH2:12]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:24](Cl)(=[O:26])[CH3:25]>C(Cl)Cl>[C:24]([N:14]1[CH2:13][CH2:12][C:11]2[C:16](=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:8]=[CH:9][CH:10]=2)[CH2:15]1)(=[O:26])[CH3:25]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 504718-Phenyl-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 233443892-Acetyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 4.2 parts of 8-phenyl-1,2,3,4-tetrahydroisoquinoline and 4 parts of triethylamine in 90 parts by volume of methylene chloride is cooled in an ice bath with stirring and 1.7 part of acetyl chloride in 10 parts by volume of methylene chloride is added slowly. The mixture is allowed to warm to ambient temperature and stirred for about 2 hours. The reaction solution is washed four times with 20 parts by volume portions of water and then dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to afford 2-acetyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline.

후처리

  1. stirringstirred for about 2 hours
  2. washThe reaction solution is washed four times with 20 parts by volume portions of water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-bd168fbdeedf4c7582465d488dfca42c
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220778

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