Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyanamide → 2-Methyl 3-(1-N-pyrrolidinyl-3-cyanopropyl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyanamide | HCID 10443 | — |
| 반응물 | 3-Bromopropionitrile | HCID 17020 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | (1-(2-Pyridinylmethyl)-15-pyrrolidin-1-yl)acetonitrile benzenesulfonate | HCID 5458873 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Methyl 3-(1-N-pyrrolidinyl-3-cyanopropyl)pyridine | HCID 23344422 | — |
반응 단계
1-cyanomethyl-1-(2-picolyl)pyrrolidinium benzenesulfonate (see Preparation II) is rearranged and alkylated with 3-bromopropionitrile as in Example 2. The resulting dicyanoamine is decyanated with sodium borohydride in ethanol to give the product. Purification is effected via the picrate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04220781 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-77ed0ada2d654ca3bda0d891202c6bc6 |
| 출처 메모 | uspto-grants-1980_09 |