Ethyl-4-acetyl-3,5-dimethylpyrrole-2-carboxylate → HCID 68561273, 화합물

HRID 272630노트

반응식

HRID 272630 반응식
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:15])=[C:9]([C:12](=[O:14])[CH3:13])[C:10]=1[CH3:11])=[O:5])[CH3:2].CC(O[CH:21](N(C)C)[N:22]([CH3:24])[CH3:23])(C)C>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:15])=[C:9]([C:12](=[O:14])[CH:13]=[CH:21][N:22]([CH3:24])[CH3:23])[C:10]=1[CH3:11])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 16947Ethyl-4-acetyl-3,5-dimethylpyrrole-2-carboxylateHCID 79885tert-Butoxy bis(dimethylamino)methane

생성물 1

HCID 68561273HCID 68561273, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

In a dry flask containing THF (15 mL) was added 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (2.0 g, 9.3 mmol) then Bredereck's reagent (5 mL). The reaction was stirred at 50° C. for 20 hours. The resulting precipitate formed during the reaction was removed by filtration and washed with hexanes. The enaminone was recovered as a yellow solid (2.2 g), HPLC Rt=4.0 minutes; FIA, ES+=265.1

후처리

  1. customThe resulting precipitate formed during the reaction
  2. customwas removed by filtration
  3. washwashed with hexanes
  4. customThe enaminone was recovered as a yellow solid (2.2 g), HPLC Rt=4.0 minutes

출처 및 근거

ORD 기록
ord-593cb93a021344148565231a66b138f0
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456190B2

반응 노트

불러오는 중…