Triethylamine → (R)-2-(2-Chloro-5-iodo-pyrimidin-4-ylamino)-3-methyl-butan-1-ol

HRID 272632

반응식

HRID 272632 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([I:9])=[CH:4][N:3]=1.C(N(CC)CC)C.[NH2:17][C@H:18]([CH:21]([CH3:23])[CH3:22])[CH2:19][OH:20]>C(#N)C.O>[Cl:1][C:2]1[N:7]=[C:6]([NH:17][C@H:18]([CH:21]([CH3:23])[CH3:22])[CH2:19][OH:20])[C:5]([I:9])=[CH:4][N:3]=1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 2634382,4-Dichloro-5-iodopyrimidineHCID 6950587D-Valinol

생성물 1

HCID 59674020(R)-2-(2-Chloro-5-iodo-pyrimidin-4-ylamino)-3-methyl-butan-1-ol

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

실험 절차

A solution of 10.05 g (36.6 mmol) of 2,4-Dichloro-5-iodo-pyrimidine and 5.6 ml (40.0 mmol) triethylamine in 30 ml of acetonitrile is mixed with 4.85 g (47.0 mmol) of (R)-2-Amino-3-methyl-butan-1-ol. The batch is stirred at room temperature for 16 hours and is finally diluted with water. The batch is filtered and the solid is washed with small amounts of acetonitrile and water. The solid is dried. 10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained.

후처리

  1. filtrationThe batch is filtered
  2. washthe solid is washed with small amounts of acetonitrile and water
  3. customThe solid is dried
  4. custom10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained

출처 및 근거

ORD 기록
ord-840b4cd1819e43acb5e41b8f14a7d16d
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456191B2

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