Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → [1-(5-Bromo-2-chloro-pyrimidin-4-ylamino)-cyclopentyl]-methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| 반응물 | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | [1-(5-Bromo-2-chloro-pyrimidin-4-ylamino)-cyclopentyl]-methanol | HCID 58890910 | — |
반응 단계
An ice-cooled solution of 2.28 g (10.0 mmol) of 5-Bromo-2,4-dichloropyrimidine and 1.7 ml (12.0 mmol) of triethylamine in 10 ml of acetonitrile is mixed with 1.38 g (12.0 mmol) (1-amino-cyclopentyl)-methanol. After 16 hours at room temperature the batch is filtrated to remove the solid precipitate. The precipitate is dried. 1.48 g (4.8 mmol, corresponding to 48% of theory) of the product is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07456191B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-4f89754d63b247c6b3faa1cdccff09da |
| 출처 메모 | uspto-grants-2008_11 |