Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 3-bromo-2-pyridinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 3-Bromopyridine-2-carboxylic Acid | HCID 2050129 | — |
| 생성물 | Methyl 3-bromo-2-pyridinecarboxylate | HCID 12828946 | 42% |
반응 단계
A mixture of 5.45 g of 3-bromo-2-pyridine carboxylic acid (27.0 mmol, 1 eq.), obtained in example 3b), in 100 ml of methanol is reflux heated in the presence of 8 ml of sulfuric acid. The reaction mixture is allowed to return to ambient temperature and poured into water. It is extracted 3 times with ethyl acetate, the organic phase is dried on Na2SO4 and vacuum evaporated. 2.48 g (42%) of esterified product is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07456192B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-eca464055933479c9ffeff3ae11eeeaa |
| 출처 메모 | uspto-grants-2008_11 |