참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | N-(tert-Butoxycarbonyl)-D-prolinol | HCID 688279 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (R)-tert-Butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate | HCID 11760051 | 45% |
반응 단계
A mixture of Boc-D-prolinol (201 mg, 1.0 mmol), p-toluenesulfonyl chloride (400 mg, 2.1 mmol), triethylamine (420 μL, 3.0 mmol), and 4-(dimethylamino)pyridine (12 mg, 0.1 mmol) in dichloromethane (10 mL) was heated at 40° C. for 48 hours, cooled to room temperature, concentrated under vacuum, diluted with ethyl acetate, washed with water and brine, dried (MgSO4), filtered, and concentrated. The residue was purified by column chromatography on silica gel to provide 160 mg (45%) of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07456169B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_11 |
|---|
| ORD ID | ord-d63fff0499e247fd9dceeb7f7da20f56 |
|---|
| 출처 메모 | uspto-grants-2008_11 |
|---|
