4-Methyl-5-(2-hydroxyethyl)thiazole → HCID 69219262, 화합물

HRID 272739

반응식

HRID 272739 반응식
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1CCO.[CH3:10][O:11][C:12]1[CH:17]=[C:16]([B:18]2[O:22][C:21]([CH3:24])([CH3:23])[C:20]([CH3:26])([CH3:25])[O:19]2)[CH:15]=[CH:14][C:13]=1[OH:27].[Br:28]C1C=CC(O)=C(OC)C=1>>[Br:28][C:4]1[S:5][CH:6]=[C:2]([CH2:1][O:27][C:13]2[CH:14]=[CH:15][C:16]([B:18]3[O:19][C:20]([CH3:26])([CH3:25])[C:21]([CH3:23])([CH3:24])[O:22]3)=[CH:17][C:12]=2[O:11][CH3:10])[N:3]=1

참가 물질

4

반응물 3

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 2622344-Bromo-2-methoxyphenolHCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

생성물 1

HCID 69219262HCID 69219262, 화합물

실험 절차

The title compound was prepared by substituting Example 652A for 2-(4-methylthiazol-5-yl)-ethanol and 2-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol for 4-bromo-2-methoxyphenol, respectively, in Example 630A. MS (ESI) m/e 426 (M+H)+; 1H NMR (300 MHz, DMSO-d.6 □ 7.77 (s, 1H), 7.25 (dd, J=8.1, 1.4 Hz, 1H), 7.15 (d, J=1.4 Hz, 1H), 7.09 (d, J=8.1 Hz, 1H), 5.15 (s, 2H), 3.77 (s, 3H), 1.28 (s, 12H).

출처 및 근거

ORD 기록
ord-49143dd23fa843aaab0a83b43a1e40d0
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456169B2

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