Ammonium Hydroxide → 1-(3-Cyanophenyl)urea
반응식
[C:1]([C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[OH-].[NH4+:13]>C1COCC1>[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH2:13])=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]참가 물질
4
실험 절차
To 3-cyanophenyl isocyanate (1.0 g, 6.90 mmol) in THF (5 mL), ammonium hydroxide (1.7 mL, 13.8 mmol) was added. The reaction was stirred for 2 h at rt. The solvent was evaporated and the crude residue was redissolved in ethyl acetate. The organic layer was washed with water and brine and dried over sodium sulfate. The solvent was evaporated and the crude residue was purified by flash column chromatography to 41A (0.37 g).
후처리
- customThe solvent was evaporated
- dissolutionthe crude residue was redissolved in ethyl acetate
- washThe organic layer was washed with water and brine
- dry with materialdried over sodium sulfate
- customThe solvent was evaporated
- customthe crude residue was purified by flash column chromatography to 41A (0.37 g)
출처 및 근거
- ORD 기록
- ord-cc36db0608964e15b7d2f4c53ebf0783
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07456195B2
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