Ethane, 2-bromo-1,1-diethoxy- → 1-Isopropyl-4-{4-[4-(1,3-thiazol-2-yl)tetrahydro-2h-pyran-4-yl]phenoxy}piperidine

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The title compound (320 mg, 74%) was prepared from 4-{4-[(1-isopropylpiperidin-4-yl)oxy]phenyl}tetrahydro-2H-pyran-4-carbothioamide and bromoacetaldehyde diethylacetal similarly to the procedure used for example 137. 1H NMR (400 MHz, CD3OD) δ 1.10 (d, 6H), 1.75-1.80 (m, 2H), 1.98-2.02 (m, 2H), 2.37-2.44 (m, 2H), 2.47-2.51 (m, 2H), 2.61-2.65 (m, 2H), 2.75-2.84 (m, 3H), 3.66-3.70 (m, 2H), 3.78-3.83 (m, 2H), 4.37 (m, 1H), 6.89 (d, 2H), 7.28 (d, 2H), 7.46 (d, 1H), 7.70 (d, 1H). RMS ESI+ m/z 387.2090 [MH]+. Microanalysis: Found: C, 67.42; H, 7.83; N, 7.08%. C22H30N2O2S. 0.2H2O requires C, 67.73; H, 7.85; N, 7.18%.

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