Thionyl Chloride → HCID 68576193, 화합물

HRID 272994노트

반응식

HRID 272994 반응식
[CH:1]([N:14]1[CH2:17][CH:16]([CH2:18]O)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>ClCCl>[ClH:22].[CH:1]([N:14]1[CH2:17][CH:16]([CH2:18][Cl:22])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 2758715(1-Benzhydrylazetidin-3-yl)methanol

생성물 1

HCID 68576193HCID 68576193, 화합물수율 168.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
2.5 °C

실험 절차

(1-Benzhydryl-azetidin-3-yl)-methanol (3.07 g, 12.1 mmol) was dissolved in dichloromethane (60 ml). The reaction was cooled to 0-5° C. and thionyl chloride (1.07 ml, 14.6 mmol) was added slowly. The reaction was allowed to warm to room temperature and stirred for 18 hours. The reaction was concentrated in vacuo and azeotroped with toluene (3×20 ml) to give the title compound (3.8 g, 100%) as a pale brown solid.

후처리

  1. temperatureto warm to room temperature
  2. concentrationThe reaction was concentrated in vacuo
  3. customazeotroped with toluene (3×20 ml)

출처 및 근거

ORD 기록
ord-487dd085125e4edcbd1de025078c0b97
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456164B2

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