Triethylamine → 2-Methylpyridine-4-carboxylic acid
반응식
[H][H].Cl[C:4]1[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[C:6]([CH3:13])[N:5]=1.C(N(CC)CC)C>[Pd].C(O)C>[CH3:13][C:6]1[N:5]=[CH:4][CH:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=1참가 물질
6
실험 절차
A hydrogen filled balloon was attached to a flask containing 2-chloro-6-methylpyridine-4-carboxylic acid (2 g, 12.0 mmol), palladium 10 wt. % on activated carbon (0.5 g), triethyl amine (4.8 ml) and ethanol (24 ml) and then stirred overnight at room temperature. The is reaction mixture was filtered through celite, washed with methanol and concentrated. The residue was titurated with dichloromethane and then filtered to afford 6-methylpyridine-4-carboxylic acid as a white solid; 1.05 g (66%). 1H NMR (MeOD) δ (ppm): 8.62 (d, 1H), 7.68 (s, 1H), 7.60 (d, 1H), 2.55 (s, 3H).
후처리
- customThe is reaction mixture
- filtrationwas filtered through celite
- washwashed with methanol
- concentrationconcentrated
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-3db16f75d17b4f68b39d141a45c58893
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07456200B2
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