Chloroacetyl chloride → 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]benzonitrile

HRID 273098노트

반응식

HRID 273098 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([NH:8][OH:9])=[NH:7])#[N:2].C(N(CC)CC)C.[Cl:20][CH2:21][C:22](Cl)=O>ClCCl>[Cl:20][CH2:21][C:22]1[O:9][N:8]=[C:6]([C:5]2[CH:4]=[C:3]([CH:12]=[CH:11][CH:10]=2)[C:1]#[N:2])[N:7]=1

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 178509779HCID 178509779, 화합물

생성물 1

HCID 578379493-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]benzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-cyano-N-hydroxy-benzamidine (1.0 g, 6.2 mmol), triethylamine (1.5 ml, 10.6 mmol) and chloroacetyl chloride (0.74 ml, 9.3 mmol) in dichloromethane (12 ml). Purification was performed by decolorizing with silica gel. 1H NMR (CDCl3), d (ppm): 8.40 (s, 1H), 8.32 (d, 1H), 7.82 (d, 1H), 7.64 (t, 1H), 4.77 (s, 2H).

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-308e46c6dd354da0877d862c15eada56
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456200B2

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