CON(C)[C:4]([C@@H:6]1[CH2:10][C:9](=[O:11])[N:8]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[CH:14][CH:13]=2)[CH2:7]1)=[O:5].[CH3:28][Mg]Br.O.C(OCC)(=O)C>O1CCCC1.C1CCCCC1>[C:4]([C@H:6]1[CH2:7][N:8]([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[CH:16][CH:17]=2)[C:9](=[O:11])[CH2:10]1)(=[O:5])[CH3:28](R)-1-[4-(3-Fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methoxy-methyl-amide (0.050 g, 0.143 mmol) was dissolved under argon in tetrahydrofurane (1 ml) and methyl magnesium bromide (0.188 mmol, 0.063 ml) was added at 0° C. The resulting solution was stirred at 0° C. for two hours. Water was added at 0° C. and the mixture was stirred for one hour. Extraction with ethyl acetate gave a residue which after chromatography on silica gel using a 9:1-mixture of ethyl acetate and cyclohexane as the eluent yielded 0.040 g (91% of theory) of the title compound as a white solid. MS: m/e=328.4 (M+H)+.
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