Diisopropylamine → 4-(7-Bromo-3-isoquinolinyl)benzonitrile

HRID 273232

반응식

HRID 273232 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](I)=[C:6](/[CH:8]=[N:9]/[C:10]([CH3:13])([CH3:12])C)[CH:7]=1.[C:15]([C:17]1[CH:22]=[CH:21]C(C#C)=[CH:19][CH:18]=1)#[N:16].C(NC(C)C)(C)C>C1(C)C=CC=CC=1.[Cu]I.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]2[C:5]([CH:13]=[C:10]([C:12]3[CH:21]=[CH:22][C:17]([C:15]#[N:16])=[CH:18][CH:19]=3)[N:9]=[CH:8]2)=[CH:4][CH:3]=1

참가 물질

7

반응물 3

HCID 7912DiisopropylamineHCID 45472454-EthynylbenzonitrileHCID 178448919HCID 178448919, 화합물

생성물 1

HCID 671042584-(7-Bromo-3-isoquinolinyl)benzonitrile

시약·촉매·용매 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 178418476HCID 178418476, 화합물촉매HCID 1140Toluene용매

실험 절차

The product from Example 62D (3.6 mmol), 4-cyanophenylacetylene (4.3 mmol), CuI (0.2 mmol), PdCl2(PPh3)2 (0.1 mmol), and diisopropylamine (5.3 mmol) can be combined in toluene (15 mL) and processed as described in Example 62E to provide the title compound.

출처 및 근거

ORD 기록
ord-87855421b6e9469eb75e3eb318c8589e
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456196B2

연결된 노트

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