Valproic Acid → (-)-Carnitine

HRID 273255

반응식

HRID 273255 반응식
[C:1]([O-:10])(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].[Mg+2:11].[OH:12][C@H:13]([CH2:19][C:20](=[O:22])[O-:21])[CH2:14][N+:15]([CH3:18])([CH3:17])[CH3:16].C([O-])(=O)C(CCC)CCC.O[C@H](CC(=O)[O-])C[N+](C)(C)C.C(O)(=O)C(CCC)CCC>O>[OH:12][C@H:13]([CH2:19][C:20](=[O:21])[O-:22])[CH2:14][N+:15]([CH3:18])([CH3:16])[CH3:17].[Mg:11].[C:1]([O-:10])(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]

참가 물질

7

반응물 3

HCID 3121Valproic AcidHCID 10917(-)-Carnitine2회HCID 86623374L-carnitine magnesium valproate4회

생성물 3

HCID 10917(-)-CarnitineHCID 3549980ValproateHCID 5462224Magnesium

시약·촉매·용매 1

HCID 962Water용매

실험 절차

As we discovered and disclose in Example 2, L-carnitine magnesium valproate, another embodiment of the present invention, is a white solid having a melting point of 77.2° C., different from the melting point of L-carnitine. The 1H-NMR spectrum of L-carnitine magnesium valproate (FIG. 3) differs from that of the starting materials (i.e., L-carnitine and valproic acid) and confirms the structure. L-carnitine magnesium valproate is nearly odorless and free from objectionable taste. L-Carnitine magnesium valproate is soluble in water, and aqueous solutions of this salt provide bioavailable L-carnitine, magnesium, and valproate.

출처 및 근거

ORD 기록
ord-03713faf71dc4e8fa2470049d9690cb2
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456216B2

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