Ammonium Chloride → 1-(6-Methoxy-benzofuran-3-yl)-ethane-1,2-diol

HRID 273335노트

반응식

HRID 273335 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH3:7][O:8][C:9]1[CH:23]=[CH:22][C:12]2[C:13]([C:16](=[O:21])[C:17](OC)=[O:18])=[CH:14][O:15][C:11]=2[CH:10]=1.[NH4+].[Cl-]>C1COCC1>[CH3:7][O:8][C:9]1[CH:23]=[CH:22][C:12]2[C:13]([CH:16]([OH:21])[CH2:17][OH:18])=[CH:14][O:15][C:11]=2[CH:10]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 21226445Aluminium lithium hydrideHCID 69194602Methyl 2-(6-methoxybenzofuran-3-yl)-2-oxoacetate

생성물 1

HCID 691973081-(6-Methoxy-benzofuran-3-yl)-ethane-1,2-diol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

LAH (0.093 g, 2.39 mmol) was added to a mixture of methyl 2-(6-methoxybenzofuran-3-yl)-2-oxoacetate (0.280 g, 1.196 mmol) in THF (10 mL) at 0° C. under N2, and the mixture was stirred overnight at room temperature under N2. An aqueous NH4Cl solution (5 mL) was added, and the reaction mixture was concentrated to half its volume and extracted with EtOAc. The organic layer was washed with brine and water, dried over anhydrous MgSO4, and evaporated to give 1-(6-methoxy-benzofuran-3-yl)-ethane-1,2-diol.

후처리

  1. concentrationthe reaction mixture was concentrated to half its volume
  2. extractionextracted with EtOAc
  3. washThe organic layer was washed with brine and water
  4. dry with materialdried over anhydrous MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-407fc36caef04f27a9e0c8ae1aef4275
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07456289B2

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