1-(6-Methoxy-benzofuran-3-yl)-ethane-1,2-diol → 6-Methoxybenzofuran-3-carbaldehyde
반응식
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]2[C:7]([CH:10]([OH:13])CO)=[CH:8][O:9][C:5]=2[CH:4]=1>C1COCC1.O>[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]2[C:7]([CH:10]=[O:13])=[CH:8][O:9][C:5]=2[CH:4]=1참가 물질
4
실험 절차
NaIO4 (0.204 g, 1.12 mmol) was added to 1-(6-methoxy-benzofuran-3-yl)-ethane-1,2-diol (0.180 g, 1.196 mmol) in THF (50 mL) and water (1 mL) with stirring. The mixture was stirred overnight at room temperature under N2. Water (10 mL) was added, and the mixture was concentrated to half its volume and extracted with EtOAc. The organic layer was washed with brine and water, dried over anhyd. MgSO4, and evaporated to give a residue, which was purified on a silica gel column eluting with EtOAc/hexane (1:10) to give 6-methoxybenzofuran-3-carbaldehyde (0.110 g, 73%).
후처리
- stirringThe mixture was stirred overnight at room temperature under N2
- concentrationthe mixture was concentrated to half its volume
- extractionextracted with EtOAc
- washThe organic layer was washed with brine and water
- customdried over anhyd
- customMgSO4, and evaporated
- customto give a residue, which
- customwas purified on a silica gel column
- washeluting with EtOAc/hexane (1:10)
출처 및 근거
- ORD 기록
- ord-48aeedf470cd4b08826f5be8112c6084
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07456289B2
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