Ethylene Glycol → 3-(1,3-Dioxolan-2-yl)-6-methoxybenzofuran
반응식
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]2[C:7]([CH:10]=[O:11])=[CH:8][O:9][C:5]=2[CH:4]=1.[OH:14][CH2:15][CH2:16]O.O>C1C=CC=CC=1>[O:11]1[CH2:16][CH2:15][O:14][CH:10]1[C:7]1[C:6]2[CH:12]=[CH:13][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[O:9][CH:8]=1참가 물질
5
실험 절차
A mixture of 6-methoxybenzofuran-3-carbaldehyde (0.600 g, 3.41 mmol), HOCH2CH2OH (3.17 g, 51 mmol) and p-toluenesulfonic acids (0.001 g) in benzene (20 mL) was refluxed for 8 h using a Dean-Stark water trap. The mixture was concentrated under reduced pressure and then diluted with EtOAc. The organic solution was washed with water, dried over anhydrous MgSO4, and concentrated to give 3-(1,3-dioxolan-2-yl)-6-methoxybenzofuran (0.711 g, 95%)
후처리
- temperaturewas refluxed for 8 h
- concentrationThe mixture was concentrated under reduced pressure
- additiondiluted with EtOAc
- washThe organic solution was washed with water
- dry with materialdried over anhydrous MgSO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-b85f95c64a904ebdba1cf6a4ca14aca7
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07456289B2
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