Dimethylcarbamoyl Chloride → 4-Dimethylcarbamoyloxy-2,5-dimethylphenyl methyl sulphide

HRID 27335노트

반응식

HRID 27335 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([S:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1[OH:11].[CH3:12][N:13]([CH3:17])[C:14](Cl)=[O:15]>N1C=CC=CC=1>[CH3:9][S:8][C:6]1[CH:7]=[C:2]([CH3:1])[C:3]([O:11][C:14](=[O:15])[N:13]([CH3:17])[CH3:12])=[CH:4][C:5]=1[CH3:10]

참가 물질

4

반응물 2

HCID 6598Dimethylcarbamoyl ChlorideHCID 12889671HCID 12889671, 화합물

생성물 1

HCID 128896874-Dimethylcarbamoyloxy-2,5-dimethylphenyl methyl sulphide

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

A mixture of 25.2 g 2,5-dimethyl-4-(methylthio)phenol and 20.3 ml dimethylcarbamoyl chloride in 70 ml dry pyridine was heated for 24 hours at 100° C. Addition to excess of ice-cold dilute hydrochloric acid gave an oil. The oil product was extracted into ether and washed three times with cold dilute sodium hydroxide and once with water, dried, and the ether removed by evaporation to give 4-dimethylcarbamoyloxy-2,5-dimethylphenyl methyl sulphide, boiling point 146° C. at 0.6 mm to 150° C. to 0.9 mm.

후처리

  1. additionAddition to excess of ice-cold dilute hydrochloric acid
  2. customgave an oil
  3. extractionThe oil product was extracted into ether
  4. washwashed three times with cold dilute sodium hydroxide
  5. dry with materialonce with water, dried
  6. customthe ether removed by evaporation

출처 및 근거

ORD 기록
ord-7230bcee4b094bab8a059f5deb486c74
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221582

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