Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 2-chloro-N-(2-methylthiazol-4-yl)methyl-N-(2,6-dimethylphenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-N-(2,6-dimethylphenyl)acetamide | HCID 70798 | — |
| 반응물 | 4-(Chloromethyl)-2-methyl-1,3-thiazole | HCID 736341 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-chloro-N-(2-methylthiazol-4-yl)methyl-N-(2,6-dimethylphenyl)acetamide | HCID 13037601 | 18% |
반응 단계
A mixture of 5.33 g N-chloroacetyl-2,6-dimethylaniline and 4 g 2-methyl-4-chloromethylthiazole (prepared in Example 4A above) in dry dimethylformamide was treated with 1.56 g sodium hydride as in Example 3 above. After workup, the solid product was purified by high-pressure liquid chromatography to yield 1.5 g pure product, m.p. 62°-64° C. This product is shown as Compound 3 in Table I. C15H17ClN2OS: calc., %C 58.35, %H 5.51, %N 9.08; found, %C 59.23, %H 5.79, %N 9.28.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04221584 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-1b9a025333954829949511d480f9dfcc |
| 출처 메모 | uspto-grants-1980_09 |