Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 2-chloro-N-(3-methylisoxazol-5-yl)methyl-N-(2,6-dimethylphenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-N-(2,6-dimethylphenyl)acetamide | HCID 70798 | — |
| 반응물 | 5-(Chloromethyl)-3-methyl-1,2-oxazole | HCID 7131496 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-chloro-N-(3-methylisoxazol-5-yl)methyl-N-(2,6-dimethylphenyl)acetamide | HCID 13037603 | 30% |
반응 단계
A mixture of 4.54 g N-chloroacetyl-2,6-dimethylaniline and 3 g 3-methyl-5-chloromethylisoxazole (prepared as in Example 8 above) in 100 ml dry dimethylformamide was treated with 1.33 g sodium hydride as in Example 3 above. After workup, the solid product was purified by column and high-pressure liquid chromatography to yield 2.0 g pure product, m.p. 78°-82° C. This product is shown as Compound 1 in Table I. C15H17ClN2O2 : calc., %C 61.54, %H 5.81, %N 9.57; found, %C, 63.37, %H 6.16, %N 9.65.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04221584 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-caf24c795a934682aa045ca65210c2ab |
| 출처 메모 | uspto-grants-1980_09 |