Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → Perindopril Erbumine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Tert-Butylamine | HCID 6385 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Perindopril | HCID 107807 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Perindopril Erbumine | HCID 441313 | — |
반응 단계
The perindopril free base is dissolved in a solvent chosen from lower aliphatic alcohol, acetonitrile, ethyl acetate or dioxane or mixtures thereof and the solution reacted with tert-butylamine to form perindopril erbumine, which is crystallized by heating the reaction mixture, filtering hot, cooling and finally filtering of the crystallized perindopril erbumine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07456296B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-d4af1cbac53a48b9b3c589b8df0e294c |
| 출처 메모 | uspto-grants-2008_11 |