Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Dicyclohexylcarbodiimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Perindopril Erbumine | HCID 441313 | — |
| 반응물 | (2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid | HCID 10015159 | — |
| 반응물 | (2S,3aS,7aS)-2-carboxyperhydroindole, p-toluenesulfonate salt | HCID 131727202 | — |
| 생성물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
반응 단계
WO 01/58868 discloses a method for preparation of perindopril erbumine comprising reacting benzyl ester of (2S,3aS,7aS)-2-carboxyperhydroindole, p-toluenesulfonate salt with (S,S) diastereoisomer of N-[(S)-1-carbethoxybutyl]-(S)-alanine in the presence of 0.4 to 0.6 moles of 1-hydroxybenzotriazole; 1 to 1.2 moles of dicyclohexylcarbodiimide and 1 mole of triethylamine at 77° C. to give the dipeptide compound, which on debenzylation gives perindopril.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07456296B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-d19c382cafa745abb9ff8c511491009a |
| 출처 메모 | uspto-grants-2008_11 |