2-(Bromomethyl)-1-methyl-1H-imidazole → HCID 178480588, 화합물

HRID 273610노트

반응식

HRID 273610 반응식
Cn1ccnc1CBr.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1>O=S(=O)(O)O.CC(C)(C)[O-].[Na+].CN(C)C=O.CN(C)C=O.CN(C)C=O.COCCOCCOC>CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1.Cn1ccnc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1

참가 물질

8

반응물 2

HCID 230435782-(Bromomethyl)-1-methyl-1H-imidazoleHCID 168301699Tert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate

생성물 2

HCID 168301699Tert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate2회HCID 178480588HCID 178480588, 화합물수율 35%

시약·촉매·용매 4

HCID 1118Sulfuric Acid시약HCID 23676156Sodium t-butoxide시약HCID 6228Dimethylformamide용매3회HCID 8150Diglyme용매

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온도
23 °C

후처리

  1. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  2. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  3. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  4. additionThe reactions were further diluted to 10 mM using DMSO.

출처 및 근거

ORD 기록
ord-17200def57eb4dfea4ab14efb96e64cb
출처 데이터셋
Cernak miniaturized N-alkylation with BOC deprotection
원본 링크
출처 보기

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