Sulfuric Acid → Carvacrol

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S(=O)(=O)(O)O.[CH3:6][C:7]1[C:12](=[O:13])[CH2:11][CH:10]([C:14]([CH3:16])=[CH2:15])[CH2:9][CH:8]=1.CN(CC1C2C=CC=CC=2NC=1)C>>[CH:11]1[C:10]([CH:14]([CH3:16])[CH3:15])=[CH:9][CH:8]=[C:7]([CH3:6])[C:12]=1[OH:13]

참가 물질

반응물 3

HCID 1118Sulfuric Acid2회

HCID 6890Gramine

HCID 7439Carvone, (+-)-

생성물 1

HCID 10364Carvacrol

실험 절차

Aqueous 0.5M sulphuric acid (25 ml), Teric N100 emulsifying agent (a product of ICI; 2.5 g) and carvone (50 g) were stirred and the emulsion passed through the CMR four times (15.5 ml/min, 165°-75° C., 690-760 kPa). Analysis was again by GC after each pass. After four passes a conversion of 50% was obtained. This experiment was then repeated using 1M sulphuric acid, and was directly comparable with experiment (a) above, the variation being the addition of the emulsifying agent. After four successive passes, the percentage of carvacrol obtained was 32%, 63%, 73% and 83%, with negligible by-product formation.

후처리

custompassed through the CMR four times (15.5 ml/min, 165°-75° C., 690-760 kPa)
customAfter four passes a conversion of 50% was obtained
additionthe addition of the emulsifying agent

출처 및 근거

ORD 기록: ord-05facc1ee4584e22b59f4faba79225cf
출처 데이터셋: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05387397

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