Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 2,2-Dimethyl-4-(6-hydroxy-3-pyridazinyloxy)-6-cyanochroman
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-bromo-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran | HCID 10244628 | — |
| 반응물 | pyridazine-3,6-diol | HCID 178516298 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 2,2-Dimethyl-4-(6-hydroxy-3-pyridazinyloxy)-6-cyanochroman | HCID 178426770 | — |
반응 단계
1.2 g of 80% NaH are added to a solution of 2.66 g of 2,2-dimethyl-4-bromo-6-cyanochroman (m.p. 89°-92°; obtainable by reduction of 2,2-dimethyl-6-cyano-4-chromanone with NaBH4, in CH3OH to give oily 2,2-dimethyl-6-cyano-4-chromanol and reaction with PBr3 in toluene at 20°) and 2.5 g of pyridazine-3,6-diol in 70 ml of DMSO and the mixture is stirred at 20° for 3 days. After customary working up, 2,2-dimethyl-4-(6-hydroxy-3-pyridazinyloxy)- 6-cyanochroman, m.p. 221°-224°, is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05387587 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-89e94ebffcf6417688bebde04fb45500 |
| 출처 메모 | uspto-grants-1995_02 |