Thiophosgene → HCID 54372553, 화합물

HRID 273772노트

반응식

HRID 273772 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].[F:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[C@:22]([OH:32])([C@H:29]([SH:31])[CH3:30])[CH2:23][N:24]1[CH:28]=[N:27][CH:26]=[N:25]1>>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:10](=[S:11])[S:31][C@@H:29]([C@:22]([C:16]1[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:15]=1[F:14])([OH:32])[CH2:23][N:24]1[CH:28]=[N:27][CH:26]=[N:25]1)[CH3:30]

참가 물질

4

반응물 3

HCID 10040ThiophosgeneHCID 111232,4-DichloroanilineHCID 1922642-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

생성물 1

HCID 54372553HCID 54372553, 화합물

실험 절차

2,4-Dichloroaniline (0.85 g) was allowed to react with thiophosgen (0.4 ml), followed by the reaction with (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-[1H-1,2,4-triazol-1-yl]-2-butanol (0.5 g) by the same manner as in Example 5. The compound (23), i.e., [(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butyl] N-(2,4-dichlorophenyl)dithiocarbamate (0.08 g) was obtained as a pale yellow oil.

출처 및 근거

ORD 기록
ord-fa8857d25bfe4a6194e353e212810df4
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387599

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