Triethylamine → HCID 18658831, 화합물

HRID 273773노트

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HRID 273773 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:19])([C@H:16]([SH:18])[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[CH3:20][N:21]([CH3:25])[C:22](Cl)=[S:23].C(N(CC)CC)C>ClCCl>[CH3:20][N:21]([CH3:25])[C:22](=[S:23])[S:18][C@@H:16]([C@:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])([OH:19])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1)[CH3:17]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 27871Dimethylthiocarbamoyl chlorideHCID 1922642-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

생성물 1

HCID 18658831HCID 18658831, 화합물수율 61.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(2R,3R)-2-(2,4-difluorophenyl)-3-mercapto1-[1H-1,2,4-triazol-1-yl]-2-butanol (0.10 g) was allowed to react with N,N-dimethylthiocarbamoyl chloride (0.13 g) in dichloromethane (3.0 ml) in the presence of triethylamine (49 ml) by the same manner as in Example 2. The compound (32), i.e., [(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butyl] N,N-dimethyldithiocarbamate (0.08 g) was obtained as colorless oil.

출처 및 근거

ORD 기록
ord-2976a2195dd04011bec8a712865d5b40
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387599

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