Propargylamine → HCID 178457545, 화합물

반응식

CS[C:3](SC)=[C:4](C(OC)=O)[C:5]#[N:6].CC1N=CNC=1CSCCN.[C:24]([C:28]([C:43]#[N:44])=[C:29](SC)[NH:30][CH2:31][CH2:32][S:33][CH2:34][C:35]1[NH:39][CH:38]=[N:37][C:36]=1[CH3:40])([O:26][CH3:27])=[O:25].C(N)C#C>>[C:24]([C:28]([C:43]#[N:44])=[C:29]([NH:6][CH2:5][C:4]#[CH:3])[NH:30][CH2:31][CH2:32][S:33][CH2:34][C:35]1[NH:39][CH:38]=[N:37][C:36]=1[CH3:40])([O:26][CH3:27])=[O:25]

참가 물질

반응물 4

HCID 239041Propargylamine

HCID 319957Methyl 2-cyano-3,3-bis(methylsulfanyl)prop-2-enoate

HCID 178433288HCID 178433288, 화합물

HCID 178500817HCID 178500817, 화합물

생성물 1

HCID 178457545HCID 178457545, 화합물

실험 절차

When 1,1-bis(methylthio)-2-carbomethoxy-2-cyanoethylene [prepared according to the procedure described in Chem. Ber., 95, 2861 (1962)] is reacted with 2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamine according to the procedure of Example 6, Step A, and the resultant 1-carbomethoxy-1-cyano-2-methylthio-2-{2-[(4-methyl-1H-imidazol-5-yl)-methylthio]ethylamino}ethylene treated with propargylamine by the procedure of Example 6, Step B, there is produced 1-carbomethoxy-1-cyano-2-(2-propynylamino)-2-{2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene.