Diethyl Ether → HCID 178419089, 화합물

HRID 273971

반응식

HRID 273971 반응식
[F:1][C:2]1[C:3]([F:11])=[C:4]([F:10])[C:5]([F:9])=[C:6]([F:8])[CH:7]=1.C(OCC)C.C([Li:21])(C)(C)C>CCCCC>[F:1][C:2]1[C:7]([Li:21])=[C:6]([F:8])[C:5]([F:9])=[C:4]([F:10])[C:3]=1[F:11]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 9696PentafluorobenzeneHCID 178418306HCID 178418306, 화합물

생성물 1

HCID 178419089HCID 178419089, 화합물

시약·촉매·용매 1

HCID 8003Pentane용매

반응 조건

온도
-65 °C

실험 절차

Inside of a 100 ml volume glass three-neck flask equipped with a 50 ml volume glass dropping funnel, temperature resistor and septum rubber was sufficiently replaced with nitrogen. Into the flask, 5 g (29.8 mmol) of pentafluorobenzene and 30 ml of diethyl ether were charged, of which solution was cooled to -65° C. Thereafter, 12.3 g (29.8 mmol) of 15.5 wt. % pentane solution of tert-butyllithium charged into the dropping funnel were added dropwise while making the inner temperature not to exceed -55° C. After the completion of dropwise addition, the reaction mixture was kept at a temperature of -65°~-55° C. with stirring to give pentafluorophenyllithium.

후처리

  1. customInside of a 100 ml volume glass three-neck flask equipped with a 50 ml volume glass
  2. additionwere added dropwise
  3. customto exceed -55° C
  4. additionAfter the completion of dropwise addition
  5. customwas kept at a temperature of -65°~-55° C.

출처 및 근거

ORD 기록
ord-e7472482fcd74fa691806aba5aefb38d
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387727

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