2,3-Dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole → 2,3-dihydro-6-methoxy-1H-isoindol-5-ol

HRID 274017

반응식

HRID 274017 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH2:13]C1C=CC=CC=1)[CH2:8][N:7](CC1C=CC=CC=1)[CH2:6]2>[OH-].[OH-].[Pd+2].C(O)C>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:5]([CH2:6][NH:7][CH2:8]2)=[CH:4][C:3]=1[OH:2]

참가 물질

4

반응물 1

HCID 107363032,3-Dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole

생성물 1

HCID 102411352,3-dihydro-6-methoxy-1H-isoindol-5-ol수율 87.4%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

To 35 mL of ethyl alcohol is added 0.5 g of 2,3-dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole. The solution is warmed until everything is dissolved. The solution is cooled to room temperature and 0.13 g of 35% palladium hydroxide on carbon is added. The resulting mixture is shaken on a Parr apparatus at 50 pounds per square inch for 21 hours. The solution is filtered through a pad of diatomaceous earth and the pad washed with ethyl alcohol. The volatiles are removed to afford 0.209 g of the desired product as a tan solid.

후처리

  1. temperatureThe solution is warmed until everything
  2. dissolutionis dissolved
  3. filtrationThe solution is filtered through a pad of diatomaceous earth
  4. washthe pad washed with ethyl alcohol
  5. customThe volatiles are removed

출처 및 근거

ORD 기록
ord-f883e3a952694f289e6e3e30256fefea
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387685

연결된 노트

불러오는 중…